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Concentration-response curves for relatively selective TAS2R agonists (colchicine, chloroquine, strychnine, and dapsone) with regard to the LPS-induced production of pro-inflammatory cytokines [TNF-α (🌑) CCL3 (■), and CXCL8 (▲)]. Lung macrophages from 5 to 9 patients were stimulated with LPS (10 ng.mL–1) in the absence or presence of TAS2R agonists. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 compared with LPS alone.
