TABLE 2.

Inhibitory effect of budesonide on the LPS-induced production of cytokines.

Cytokine (ng/106 LMs)	LPS	LPS + Bud 10 nM	Inhibition (%)
TNF-α n = 5	64.8 ± 9.4	8.2 ± 2.3 ∗∗	88.2 ± 3.0
CCL3 n = 5	277.3 ± 29.1	22.1 ± 5.9 ∗∗∗	92.2 ± 2.1
CXCL8 n = 5	1851.7 ± 209.2	78.3 ± 13.1 ∗∗∗	95.8 ± 1.2
IL-10 n = 5	3.2 ± 2.0	0.16 ± 0.06 ∗∗∗	95.2 ± 1.0

Human LMs were incubated for 1 h in the presence of budesonide (10 nM) or vehicle before being stimulated with LPS (10 ng.mL^–1) for 24 h. The concentrations of the cytokines in the culture supernatant were measured using ELISAs. The data are reported as the mean ± SEM of five independent paired experiments. ^∗ indicates a significant difference relative to LPS alone (^∗∗p < 0.01 and ^∗∗∗p < 0.001).