Table 2.
BoNT/A1 amino acid determination of neutralizing epitopes shown in Figure 1.
| Binding Domain | Reference | |
|---|---|---|
| HC domain: | C25: 889 to 1294 | Mullaney et al. 2001 Levy et al. 2007 |
| HuC25: 918–920; 953; 1061–1066 | ||
| 3D12: 1127–1131; 1131–1264 | ||
| S25: 1115–1223; 1254–1256 | ||
| HN domain: | N5: 505–523 | Atassi 2005 |
| N6: 519–537 | ||
| N8: 547–565 | ||
| N25: 785–803 | ||
| N26: 799–817 | ||
| Hc domain: | C2: 869–887 | |
| C3: 883–901 | ||
| C4: 897–915 | ||
| C9–11: 967–1013 | ||
| C13: 1023–1041 | ||
| C15: 1051–1069 | ||
| C23: 1163–1181 | ||
| C25: 1191–1209 | ||
| C31: 1275–1296 | ||
| N28: 827–845 | ||
| HN domain: | 455–662 | Dertzbaugh 1996 |
| HC domain: | 1150–1289 | |