Table 2.

Moderator analyses

Moderators		TST	WASO	SE	N1 percentage	N2 percentage	SWS percentage	REM percentage	REM latency	PLMI	AI	AHI
Sex (female%)	No. of comparison	6	4	6	6	6	6	6	5	4	5	5
	No. of H/C	121/119	96/93	121/119	121/119	121/119	121/119	121/119	91/89	96/93	105/103	105/103
	Point estimate	0.32	−3.60	1.10	−0.50	3.43	0.13	−1.25	−0.37	−5.63	4.21	−1.15
	SE	4.47	9.10	4.67	2.78	2.75	4.20	4.27	4.09	11.09	7.77	3.82
	P	0.94	0.69	0.81	0.83	0.21	0.98	0.77	0.93	0.61	0.59	0.76
Mean age of HD patients	No. of comparison	6	4	6	6	6	6	6	5	4	5	5
	No. of H/C	121/119	96/93	121/119	121/119	121/119	121/119	121/119	91/89	96/93	105/103	105/103
	Point estimate	−0.07	0.10	−0.08	0.02	−0.02	−0.08	−0.11	0.12	0.09	0.08	−0.01
	SE	0.04	0.03	0.04	0.03	0.04	0.04	0.03	0.05	0.05	0.05	0.03
	P	0.10	0.003	0.08	0.34	0.55	0.03	<0.001	0.016	0.09	0.14	0.67
BMI (kg/m2)	No. of comparison	4	4	4	4	4	4	4	3	4	4	4
	No. of H/C	96/93	96/93	96/93	96/93	96/93	96/93	96/93	66/63	96/93	96/93	96/93
	Point estimate	0.28	−0.36	0.28	−0.10	0.10	0.28	0.44	−0.43	−0.34	−0.37	0.11
	SE	0.25	0.13	0.26	0.13	0.14	0.24	0.13	0.20	0.20	0.20	0.13
	P	0.26	0.006	0.28	0.43	0.47	0.25	<0.001	0.03	0.08	0.07	0.36
CAG repeats (n)	No. of comparison	4	4	4	4	4	4	4	3	3	3	3
	No. of H/C	115/109	115/109	115/109	115/109	115/109	115/109	115/109	85/79	84/84	84/84	84/84
	Point estimate	−0.23	0.13	−0.39	0.13	0.05	−0.57	−0.29	0.17	0.20	0.81	−0.003
	SE	0.39	0.24	0.36	0.13	0.18	0.24	0.26	0.17	1.05	0.88	0.29
	P	0.56	0.58	0.28	0.33	0.76	0.017	0.26	0.33	0.85	0.36	0.99
Disease severity
Excluding Piano study	No. of comparison	6	4	6	6	6	6	6	6	3	4	4
	No. of H/C	122/114	97/88	122/114	122/114	122/114	122/114	122/114	122/114	66/63	75/73	75/73
	SMD	−0.109	0.520**	−0.615***	0.386**	−0.006	−0.286	−0.402*	0.425*	0.260	−0.093	−0.130
	Q	6.150	1.752	6.155	1.783	8.325	7.209	6.924	9.659	6.145	1.466	1.730
	I 2	18.696	0	18.768	0	39.941	30.638	27.792	48.235	67.452*	0	0
Excluding Piano and Lazar studies	No. of comparison	5	3	5	5	5	5	5	5	3	4	4
	No. of H/C	91/89	66/63	91/89	91/89	91/89	91/89	91/89	91/89	66/63	75/73	75/73
	SMD	−0.138	0.428*	−0.699***	0.443**	−0.003	−0.412**	−0.426*	0.410	0.260	−0.093	−0.130
	Q	6.139	0.859	5.327	1.189	8.027	3.055	6.807	9.641	6.145	1.466	1.730
	I 2	34.842	0	24.913	0	50.169	0	41.236	58.511*	67.452*	0	0
Adaptation
No	No. of comparison	4	4	4	4	4	4	4	3	4	4	4
	No. of H/C	96/93	96/93	96/93	96/93	96/93	96/93	96/93	66/63	96/93	96/93	96/93
	SMD	−0.334	0.663*	−0.888*	0.473	0.170	−0.620	−0.698*	0.472	0.518	0.319	−0.257
	Q	18.619	9.082	17.607	1.321	3.143	15.691	12.338	5.671	15.010	17.535	1.010
	I 2	83.888***	66.969*	82.962***	0	4.555	80.880**	75.685**	64.734	80.013**	82.891**	0
Yes	No. of comparison	3	1	3	3	3	3	3	3	—	1	1
	No. of H/C	56/51	31/25	56/51	56/51	56/51	56/51	56/51	56/51	—	9/10	9/10
	SMD	−0.232	0.740**	−0.847**	0.397	−0.306	−0.384	−0.375	0.337	—	−0.500	0.322
	Q	0.802	0	4.117	1.402	1.792	6.282	3.679	3.119	—	0	0
	I 2	0	0	51.426	0	0	68.161*	45.633	35.880	—	0	0
Between group difference	Q	0.067	0.039	0.007	0.096	3.711	0.209	0.578	0.109	—	1.880	1.429
	P	0.795	0.843	0.933	0.756	0.054	0.647	0.447	0.741	—	0.170	0.232
PSG scoring methods
AASM	No. of comparison	2	2	2	2	2	2	2	1	2	2	2
	No. of H/C	59/59	59/59	59/59	59/59	59/59	59/59	59/59	29/29	59/59	59/59	59/59
	SMD	−0.400	0.897	−1.103	0.473*	0.173	−1.019	−0.911	0.790**	0.546	0.595	−0.257
	Q	18.489	6.438	16.406	1.307	3.013	8.528	8.922	0	13.008	14.898	0.524
	I 2	94.591***	84.467*	93.905***	23.478	66.814	88.275**	88.792**	0	92.312***	93.288***	0
R&K	No. of comparison	4	3	4	4	4	4	4	4	2	3	3
	No. of H/C	77/69	68/59	77/69	77/69	77/69	77/69	77/69	77/69	37/34	46/44	46/44
	SMD	−0.242	0.573**	−0.609***	0.414*	−0.059	−0.117	−0.543*	0.449	0.526	−0.055	−0.135
	Q	0.884	1.485	2.677	1.437	3.513	3.897	4.608	5.346	1.914	1.386	1.728
	I 2	0	0	0	0	14.604	23.008	34.893	43.882	47.755	0	0
Between group difference	Q	0.035	0.375	0.341	0.047	0.391	2.156	0.343	0.890	0.001	0.695	0.186
	P	0.852	0.540	0.559	0.828	0.532	0.142	0.558	0.346	0.980	0.404	0.666

AASM, American academy of sleep medicine; AHI, apnea hypopnea index; AI, arousal index; BMI, body mass index; Q, Cochran’s Q statistic; REM, rapid eye movement sleep, H/C, Huntington disease/control; PLMI, periodic limb movements index; R&K, Rechtschaffen and Kales; SWS, slow wave sleep; SE, sleep efficiency; TST, total sleep time.

*p < 0.05, **p < 0.01, ***p < 0.001.