Table 4.
Clinical application of NDV (Part II): Multimodal cancer immunotherapy combining hyperthermia/NDV pretreatment with active-specific vaccination via IO-VACR.
| Single-case Report of Prostate Cancer with Extensive Bone Metastases |
| Single-case report of breast cancer with extensive liver metastases |
| Retrospective analysis of adults with GBM (median age 60) (n = 63) |
| Retrospective analysis of children (median age 6.5–9.5) (n = 76) with brain cancer; among them diffuse intrinsic pontine glioma (DIPG) (n = 28) 2015: IOZK succeeded in producing oncolytic NDV (derivative from strain Mukteshwar) from cell culture at high titers and with high purity according to GMP guidelines and received a permit for its use in cancer patients. This is used to produce the autologous NDV viral oncolysate-pulsed DC vaccine IO-VACR. |