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Future perspectives.
| OV-mediated gene therapy, incorporation of therapeutic genes |
| Improving tumor targeting of OVs by carrier cells |
| Improving T-cell costimulation by bi- or tri-specific antibodies |
| Improving OV targeting of immune cells by loading the cells with tri-specific antibodies |
| Combining OV therapy with checkpoint inhibitors |
| Combining OV therapy with physical modalities such as mEHT |
| Combining OV therapy with pharmacological modulation |
