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Internalization of extracellular dsRNA. dsRNA in the extracellular milieu bind to uptake receptors on the cell surface and are endocytosed, mediated by Raftlin, in a clathrin-dependent manner. dsRNA activate TLR3 in endosomes and then SIDT2 urgse them to exit from the endosome to the cytosol. In the cytosol, RLR recognize dsRNA.
