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. 2019 Jul 3;8(3):41. doi: 10.3390/antib8030041

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Generations of CAR-T cell therapeutics. Generations of CAR-T cell therapeutics as described in the text. (A) Generalized drawing of a CAR-T showing the fusion of the scFv to the transmembrane domain and intracellular activation domains. (B) Drawing depicting examples of first generation (1–3), second generation (4, 5) and third generation (6–9) CAR-T constructs as described in the text.