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. 2019 Jul 3;8(3):41. doi: 10.3390/antib8030041

Figure 5.

Figure 5

Diagram of the T-cell receptor (TCR) complex. Normal TCR-pMHC interactions are in the range of 1–100 µM, with the inherent avidity of clustered TCRs providing the required attraction [11]. Affinities of the MHC to the presented peptide have a profound influence on the ability of natural T cells to kill and eradicate tumors. When the peptide-MHC affinity was found to be <10 nM as determined in in vitro assays, it was shown that T cells recognizing those pMHC complexes were able to cause tumor rejection [116]. On the other hand, when the peptide-MHC affinity was >100 nM, the tumors relapsed, indicating that the T cells were not capable of killing those tumors cells [116]. Both CAR-T cells and TRBAs function independently of this parameter.