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. 2019 Jul 3;8(3):41. doi: 10.3390/antib8030041

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of various CAR formats. Left, natural organization of a CD8⁺ TCR expressed on cytotoxic T cells driving MHC-restricted CD8⁺ T cell effects. TCR-CARs are formed by fusing the TCR α/β variable domains to a second-generation CAR scaffold. The Eureka Therapeutics Artemis platform fuses antibody variable domains to TCR α/β constant regions. TCR2 platform fuses scFvs to CD3ε. Triumvira platform fusing two scFv chains to CD8 stalk, hinge and intracellular domains-one scFv binds to CD3ε engaging the rest of the TCR complex, while the second is free to interact with tumor antigens.