Table 1.
Comparison of nasal and intestinal mucosal immunity
| Nasal mucosal immunity | Intestinal mucosal immunity | Ref. | |
|---|---|---|---|
| Inductive sites | NALT | Peyer's patch and isolated lymphoid follicles | 7, 12 |
| Effective sites | Upper airways, lacrimal, nasal, and salivary glands | Small and large bowels | 7, 12 |
| T cells | Naïve T cell | Memory T cell | 18, 19 |
| B cells | CD62L, α4β1, CCR7, CCR10 | α4β7, α4β1, CCR9, CCR10 | 13–17 |
| DCs | CD103+CD11b– | CD103–CD11b– | 9, 20, 21 |
| CD103+CD11b+ | CD103+CD11b–CD8α+CX3CR1– | ||
| PDCA-1+ pDC | CD103+CD11b+CX3CR1low | ||
| CD11b+CD64–F4/80– | CD103–CD11b+CX3CR1int | ||
| Macrophages | CD11b+CD64+F4/80+ | CD64+CX3CR1hi | 9, 20, 21 |
| Immune response | Th1/Th2 | Th2 > Th1 | |
DCs, dendritic cells; NALT, nasal associated lymphoid tissue.