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. 2019 Sep 13;11(9):533. doi: 10.3390/toxins11090533

Table 1.

Dissociation constants (Kds) of anti-CTX mAbs against synthetic fragments and marine toxins 1.

mAb Kd (nM)
15 16 17 18 CTX1B CTX3C 51-hydroxy-CTX3C BTX-A BTX-B OA MTX
10C9 0.8 NI ND ND ND 2.8 ND NI NI NI NI
3D11 NI 8.6 ND ND ND 122 ND 43000 NI NI NI
8H4 ND ND 48 ND 20.4 3200 13.6 NI NI NI NI
3G8 ND ND ND 1.5 15 NI ND NI NI NI ND

1 The Kd’s were determined by competitive ELISA. ND: not determined. NI: no inhibition was observed at the maximum concentration of each inhibitor (for 10C9, 250 μM 16, 100 μM BTX-A, 100 μM BTX-B, 100 μM OA, 25 μM MTX; for 3D11, 250 μM 15, 100 μM BTX-A, 100 μM BTX-B, 100 μM OA, 25 μM MTX; for 8H4, 100 μM BTX-A, 100 μM BTX-B, 100 μM OA, 25 μM MTX; for 3G8, 1.9 μM CTX3C, 10 μM BTX-A, 100 μM BTX-B, 100 μM OA).