HBsAg mutations outside the major hydrophilic region (MHR) reported in patients suffering from HBV reactivation; in blue—N-terminal region of HBsAg, aa1–98; in orange—MHR, aa99–169; in green—C-terminal region of HBsAg, aa170–226; Ref—reference [67,68,73,74,76,80,81,83,88].