Table 1.
Description and frequency of resident-memory markers on CD8 bTRM during CNS viral infections.
| TRM Marker | Function | Frequency of Marker Expression on CD8 bTRM during Brain Infection | ||
|---|---|---|---|---|
| Acute Infections: | Persistent Infections: | |||
| CD103 | Binds to E-cadherin | VSV: ≤90% LCMV: ≤60% MCMV: <40% |
MuPyV, T. Gondii: 40–60% WNV: <20% |
[11,19,51,52,53,54] |
| CD69 | Antagonizes S1PR1 expression | VSV, LCMV: >80% MCMV: <60% |
MuPyV, T. Gondii: >80% HSV: <40% |
[19,51,52,53,55,56,57] |
| PD-1 | Inhibitory receptor, antagonizes TCR engagement | VSV: <1% MCMV: <25% JHMV: 20–45% |
MuPyV: >90% T. Gondii: 30–50% WNV: 20–30% |
[11,58,59,60,61] |
| CD62L | Lymphocyte-endothelial cell interactions | MCMV: <5% | MuPyV: <5% | [57,62] |
| Ki67 | General marker of cellular proliferation | JHMV: <5% | MuPyV: <20% | [19,63] |
| Granzyme-B | Mediates apoptosis in target cells | LCMV: <60% VSV: >30% JHMV: >20% |
WNV: <20% | [11,16,51,63] |
| IFNγ (after stimulation) | Pleiotropic cytokine | JHMV: >30% MCMV: >60% LCMV: >50% |
MuPyV: <60% WNV: <10% |
[16,51,57,60,64,65] |
The frequency of CD8 bTRM expressing canonical TRM markers during different virus infections of the brain is shown. Frequencies listed are from CD8 T cells analyzed during days 15 to >30 post infection.