Table 4.
Multivariable regression shrinkage analyses results: associations between dopamine regulation SNPs and cognitive test z-scores
| N | DSF | DSB | TMT-A | TMT-B | BTA | VF | HVLT-L | HVLT-D | HVLT-DI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs4532 | CC (ref) | 18 | |||||||||
| DRD1 | CT | 69 | 0.38(0.24)* | 0.28(0.26)* | 0.59(0.27) ** | ||||||
| TT | 63 | 0.18(0.24)∆ | 0.49(0.27) ** | 0.45(0.27) ** | |||||||
| rs3758653 | TC,CC (ref) | 65 | |||||||||
| DRD4 | TT | 85 | 0.27(0.19) * | −0.24(0.18)* | 0.36(0.19) ** | ||||||
| rs34863235 | CC (ref) | 102 | |||||||||
| ANKK1 | TC,TT | 48 | 0.29(0.20)* | −0.34(0.20) ** | |||||||
| rs165774 | AG,AA (ref) | 68 | |||||||||
| COMT | GG | 82 | −0.49(0.21) ** | ||||||||
| rs165815 | AA (ref) | 101 | |||||||||
| COMT | AG,GG | 49 | −0.37(0.23)* | −0.33(0.22)* | −0.66(0.26) ** | −0.61(0.25) ** | −0.42(0.26) ** | −0.33(0.25)* | |||
| rs174696 | AA (ref) | 95 | |||||||||
| COMT | AG,GG | 55 | −0.43(0.24) ** | ||||||||
| rs740603 | AA (ref) | 29 | |||||||||
| COMT | AG | 68 | 0.36(0.26)* | 0.31(0.30)* | 0.46(0.28) ** | 0.38(0.29)* | |||||
| GG | 53 | 0.12(0.30)∆ | −0.56(0.36)* | −0.08(0.33)∆ | −0.03(0.34)∆ | ||||||
| rs9332377 | AG,AA (ref) | 54 | |||||||||
| COMT | GG | 96 | −0.35(0.22)* | −0.35(0.26)* | −0.37(0.23)* | −0.49(0.25) ** | −0.34(0.23)* |
∆, PAS < 0.90; *PAS ≥ 0.90; **PAS ≥ 0.95
DSF = Digit Span Forward; DSB = Digit Span Backward; TMT-B = Trail Making Test, Part B; BTA = Brief Test of Attention; VF = Verbal Fluency Test; HVLT- L = Hopkins Verbal Learning Test‒Learning; HVLT-D = Hopkins Verbal Learning Test‒Delayed Recall; HVLT-DI = Hopkins Verbal Learning Test‒Discrimination Index.
Beta and standard error values for 8 SNPs retained in the multivariate regression models, controlling for age, education, treatment with RT ± CT, time since treatment, and tumor location.
Blank cells indicate that the SNP was not associated with the given cognitive test. SNPs and cognitive tests showing very strong (PAS ≥ 0.95) and strong (PAS ≥ 0.90) associations are included.
For SNPs with 3 categories, the effects and standard error of both categories are included even if only one category had PAS ≥ 0.95.