Table 5.
Multivariable regression shrinkage analyses results: associations between myelin regulation SNPs and cognitive test z-scores
| N | DSF | DSB | TMT-A | TMT-B | BTA | VF | HVLT-L | HVLT-D | HVLT-DI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs12898861 | AA(ref) | 25 | |||||||||
| LINGO-1 | AG | 72 | 0.01(0.22)∆ | ||||||||
| GG | 53 | −0.46(0.23) ** | |||||||||
| rs11072660 | AA(ref) | 32 | |||||||||
| LINGO1 | AG | 74 | 0.36(0.22) ** | 0.32(0.23)∆ | |||||||
| GG | 44 | −0.10(0.25)* | −0.14(0.26) * | ||||||||
| rs1217569 | AG,A(ref) | 55 | |||||||||
| TCF4 | GG | 95 | 0.38(0.20) ** | ||||||||
| rs3760609 | AA(ref) | 20 | |||||||||
| TCF4 | AG | 70 | −0.19(0.21)∆ | −0.21(0.22)∆ | |||||||
| GG | 60 | 0.39(0.24) ** | 0.32(0.22)* | ||||||||
| rs3760620 | AA(ref) | 92 | |||||||||
| TCF4 | GG,AG | 58 | 0.39(0.19) ** | 0.38(0.22) ** | 0.28(0.20)* | 0.28(0.21)* | |||||
| rs7989554 | AA(ref) | 23 | |||||||||
| TNFRSF19 | AC | 71 | −0.04(0.22)∆ | −0.48(0.23) ** | |||||||
| CC | 56 | −0.36(0.25)* | −0.18(0.25)∆ | ||||||||
| rs9507406 | AA(ref) | 111 | |||||||||
| TNFRSF19 | AG,GG | 39 | 0.39(0.21) ** | 0.49(0.23) ** | |||||||
| rs9511424 | AG,AA(ref) | 56 | |||||||||
| TNFRSF19 | GG | 94 | −0.32(0.21) ** | −0.36(0.22) ** |
∆, PAS < 0.90; *PAS ≥ 0.90; **PAS ≥ 0.95
DSF = Digit Span Forward; DSB = Digit Span Backward; TMT-B = Trail Making Test, Part B; BTA = Brief Test of Attention; VF = Verbal Fluency Test; HVLT- L = Hopkins Verbal Learning Test‒ Learning; HVLT-D = Hopkins Verbal Learning Test‒Delayed Recall; HVLT-DI = Hopkins Verbal Learning Test‒Discrimination Index.
Beta and standard error values for 8 SNPs retained in the multivariate regression models, controlling for age, education, treatment with RT ± CT, time since treatment, and tumor location.
Blank cells indicate that the SNP was not associated with the given cognitive test. SNPs and cognitive tests showing very strong (PAS ≥ 0.95) and strong (PAS ≥ 0.90) associations are included. For SNPs with 3 categories, the effects and standard error of both categories are included even if only one category had PAS ≥ 0.95