Table 6.
Multivariable regression shrinkage analyses results: associations between DNA repair, cell cycle regulation, and response to oxidative stress SNPs and cognitive test z-scores
| N | DSF | DSB | TMT-A | TMT-B | BTA | VF | HVLT-L | HVLT-D | HVLT-DI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs7075748 | AA (ref) | 68 | |||||||||
| MGMT (DNA repair) | AG,GG | 82 | −0.27(0.19)* | −0.45(0.21) ** | |||||||
| rs12593359 | AA (ref) | 42 | |||||||||
| RAD51 (DNA repair) | AC | 72 | −0.01(0.19)∆ | −0.10(0.20)∆ | −0.16(0.19)∆ | −0.09(0.20)∆ | −0.08(0.19)∆ | ||||
| CC | 36 | . | −0.30(0.21)* | −0.35(0.23)* | −0.36(0.22)* | −0.34(0.23)* | −0.38(0.21) ** | ||||
| rs1286254 | AA (ref) | 46 | |||||||||
| TDP1 (DNA repair) | AG | 72 | −0.36(0.21) ** | ||||||||
| GG | 32 | −0.01(0.23)∆ | |||||||||
| rs12493301 | AA (ref) | 43 | |||||||||
| XPC (DNA repair) | AG | 64 | −0.39(0.20) ** | −0.28(0.21)* | −0.22(0.20)∆ | ||||||
| GG | 43 | −0.13(0.20)∆ | −0.15(0.20)∆ | −0.26(0.20)* | |||||||
| rs6708185 | AA (ref) | 35 | |||||||||
| XRCC5 (DNA repair) | AG | 77 | −0.01(0.21)∆ | 0.20(0.20)∆ | |||||||
| GG | 38 | −0.29(0.22)* | −0.37(0.21) ** | ||||||||
| rs12484029 | AA (ref) | 71 | |||||||||
| XRCC6 (DNA repair) | AG | 62 | −0.27(0.19)* | −0.38(0.20) ** | −0.28(0.18)* | ||||||
| GG | 17 | −0.20(0.23)∆ | −0.24(0.23)∆ | −0.06(0.22)∆ | |||||||
| rs1951358 | AA,AG (ref) | 53 | |||||||||
| SESN1 (Cell Cycle) | GG | 97 | −0.57(0.32) ** | ||||||||
| rs911475 | AA,AG (ref) | 33 | |||||||||
| SESN1 (Cell Cycle) | GG | 117 | −0.58(0.33) ** | ||||||||
| rs11807 | AA (ref) | 105 | |||||||||
| GSTM3 (Oxidative) | AG,GG | 45 | 0.41(0.20) ** | ||||||||
| rs947895 | AA,AC (ref) | 77 | |||||||||
| GSTP1 (Oxidative) | CC | 73 | −0.64(0.32) ** |
∆, PAS < 0.90; *PAS ≥ 0.90; **PAS ≥ 0.95
DSF = Digit Span Forward; DSB = Digit Span Backward; TMT-B = Trail Making Test, Part B; BTA = Brief Test of Attention; VF = Verbal Fluency Test; HVLT-L = Hopkins Verbal Learning Test‒Learning; HVLT-D = Hopkins Verbal Learning Test‒Delayed Recall; HVLT-DI = Hopkins Verbal Learning Test‒Discrimination Index.
Beta and standard error values for 6 SNPs (DNA Repair); 2 SNPs (Cell Cycle); 2 SNPs (Oxidative Stress) retained in the multivariate regression models, controlling for age, education, treatment with RT ± CT, time since treatment, and tumor location.
Blank cells indicate that the SNP was not associated with the given cognitive test. SNPs and cognitive tests showing very strong (PAS ≥ 0.95) and strong (PAS ≥ 0.90) associations are included.
For SNPs with 3 categories, the effects and standard error of both categories are included even if only one category had PAS ≥ 0.95.