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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Clin Pharmacol Ther. 2019 Mar 12;106(1):204–210. doi: 10.1002/cpt.1372

Table 2.

Estimates of variance components from the mixed effects model

Estimates of variance by trial Estimate P-value
099–14
 Patient 988.7 <0.0001
 Treatment-by-patient 166.0 0.0202
 Residual 1244.5
CP-043
 Patient 1163.7 <0.0001
 Treatment-by-patient 249.2 0.0009
 Residual 1142.3
FEN-201
 Patient 823.7 <0.0001
 Treatment-by-patient 133.8 0.0878
 Residual 1194.8
INS-05–001
 Patient 1110.4 <0.0001
 Treatment-by-patient 287.6 0.0001
 Residual 1473.7