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Association between GRS and severe CAD in subgroups of the participants with and without demographic characteristics, lifestyle factors, and comorbidities. All ORs were calculated per SD increase in GRS. All analyses were adjusted for age and sex, except for age and sex subgroup. Prior CVD included prior myocardial infarction, prior revascularization, heart failure, stroke/transient ischemic arrack, chronic angina and peripheral vascular disease
