Table 2.
The associations of present T2D and T2D-GRS with multi-vessel disease
| T2D cases/total subjects | Model 1a | Model 2b | Model 3c | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| Present T2D | 288/1414 | 1.79 (1.33–2.44) | < 0.001 | 1.69 (1.25–2.32) | < 0.001 | – | – |
| Continuous variable of GRS | |||||||
| Per SD (3.81 points) | 1.23 (1.10–1.37) | < 0.001 | 1.21 (1.08–1.36) | < 0.001 | 1.16 (1.03–1.31) | 0.012 | |
| Per risk allele | 1.06 (1.02–1.09) | < 0.001 | 1.05 (1.02–1.08) | < 0.001 | 1.04 (1.01–1.07) | 0.012 | |
| Categorical variable of GRS | |||||||
| Low risk | 43/472 | 1.00 | 0.011 | 1.00 | 0.021 | 1.00 | 0.126 |
| Medium risk | 78/471 | 1.12 (0.86–1.47) | 1.11 (0.84–1.46) | 1.08 (0.82–1.42) | |||
| High risk | 167/471 | 1.43 (1.08–1.89) | 1.39 (1.05–1.84) | 1.25 (0.94–1.67) | |||
aAdjust for age, sex and BMI
bAdjust for age, sex, BMI, smoking, hypertension, and hypercholesterolemia
cAdjust for age, sex, BMI, smoking, hypertension, hypercholesterolemia, and T2D