Table 2.
Clinical and laboratory parameters of participants with sickle cell disease
| Parameters | All participants (n=245) | Males (n=122) | Females (n=123) |
|---|---|---|---|
| SCD complications (%) | |||
| Priapism* | * | 37 (30.3) | * |
| Leg ulcers | 50 (20.4) | 31 (21.4) | 19 (15.4) |
| Acute chest syndrome | 34 (13.9) | 17 (13.9) | 17 (13.8) |
| AVN of femoral head | 19 (7.7) | 7 (13.9) | 12 (9.8) |
| Nephropathy | 11 (4.4) | 4 (3.3) | 5 (4.1) |
| Stroke | 3 (1.2) | 2 (1.6) | 1 (0.8) |
| Pulmonary hypertension | 3 (1.2) | 2 (1.6) | 1 (0.8) |
| Cholelithiasis | 3 (1.2) | 0 | 3 (1.3) |
| Heart failure | 3 (1.2) | 0 | 3 (1.3) |
| Laboratory parameters# | |||
| Hemoglobin g/dL (mean±SD) | 7.8±1.6 | 8.0±1.7 | 7.65±1.46 |
| PCV % (mean±SD) | 23.1±5.1 | 23.72±5.5 | 22.56±4.66 |
| HbF % (median (IQR) | 4.8 (2.6-8.4) | 4.4 (2.6-7.8) | 5.5 (2.7-8.8) |
| WBC/mL (median (IQR) | 9400.0 (7400-11575) | 9300.0 (7400.0-11500.0) | 9800 (7500-11600) |
| Neutrophil/mL (median (IQR) | 5300.0 (3900-6900) | 5100.0 (3900.0-7000.0) | 5550 (4100-6850) |
| Lymphocyte/mL (median (IQR) | 3400.0 (2600-4300) | 3200.0 (2700.0-4250.0) | 3500 (2525-4375) |
| Platelet count/mL (median (IQR) | 271,500.0 (193,000-355,250) | 249000.0 (19000.0-36000.0) | 283000 (213000-338000) |
*Males only, #Complete blood count and Hemoglobin F for 188 (91 males) and 196 (98 males) participants respectively. SCD=Sickle cell disease, PCV=Packed cell volume, HbF=Fetal hemoglobin, WBC=White cell count, IQR=Interquartile range, AVN=Avascular necrosis