Table 4.
Comparison of pulmonary function parameters among participants with sickle cell disease and controls
| Parameter | All participants (n=461) | Males (n=299) | Females (n=232) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SCD (n=245) | Control (n=216) | Statistics | SCD (n=122) | Control (n=107) | Statistics | SCD (n=123) | Control (n=109) | Statistics | |
| Measured values | |||||||||
| Median FEV1 in liters (IQR) | 2.42 (2.12-2.89) | 3.08 (2.60-3.59) |
Z=−8.9, P=<0.001 |
2.87 (2.37-3.32) | 3.49 (3.19-4.0) |
Z=−8.2, P=<0.001 |
2.20 (1.91-2.49) | 2.61 (2.33-2.92) |
Z=−6.80, P=<0.001 |
| Median FVC in liters (IQR) | 3.06 (2.63-3.68) | 3.55 (3.09-4.32) |
Z=−7.1, P=<0.001 |
3.49 (3.09-3.99) | 4.28 (3.79-4.70) |
Z=−7.5, P<0.001 |
2.72 (2.42-3.06) | 3.11 (2.78-3.44) |
Z=−5.24, P=<0.001 |
| Median FEV1/FVC (IQR) | 0.81 (0.75-0.87) | 0.85 (0.80-0.89) |
Z=−4.7, P<0.001 |
0.81 (0.76-0.86) | 0.84 (0.80-0.89) |
Z=−3.1, P=0.002 |
0.80 (0.75-0.87) | 0.85 (0.80-0.88) |
Z=−3.57, P=<0.001 |
| Pattern | |||||||||
| Normal (%) | 71 (29.0) | 148 (68.5) |
χ2=98.39, P=<0.001 |
36 (29.5) | 74 (69.2) |
χ2=41.51, P=<0.001 |
35 (28.5) | 74 (67.9) |
χ2=37.68, P=<0.001 |
| Suggestive of restrictive (%) | 118 (48.2) | 50 (23.1) | 65 (53.3) | 29 (27.1) | 53 (43.1) | 21 (19.3) | |||
| Obstructive (%) | 29 (11.8) | 16 (7.4) | 6 (4.9) | 4 (3.7) | 23 (18.7) | 12 (11.0) | |||
| Mixed (%) | 27 (11.0) | 2 (0.9) | 15 (12.3) | 0 (0) | 12 (9.8) | 2 (1.8) | |||
FEV1=Forced expiratory volume in the 1st s, SCD=Sickle cell disease, FVC=Forced vital capacity