Figure 2.

Ibrutinib treatment leads to increased numbers of mature hepatic granulomas. All groups of mice were euthanized on day 28 after infection, and livers were harvested and analyzed for formation of granulomas. Liver sections were prepared and stained with hematoxylin-eosin to enumerate granuloma formation. A, Images of hepatic granulomas from all groups at 100× and 400× the original magnification. B, Liver sections were scored for the number of granulomas. Data represent the number of granulomas per 10 high-power fields at 200× the original magnification and are indicated as mean ± standard error of the mean from one of the 3 independent experiments, with ≥5 mice/group. PBS, phosphate-buffered saline; SSG, sodium stibogluconate. **P < .01, by the unpaired t test.