Table 2.
Parameter | Baseline | 3 mo | 6 mo | 1 y |
---|---|---|---|---|
BSA, m2 | 1.87 ± 0.21 | 1.87 ± 0.23 | 1.89 ± 0.22^ | 1.92 ± 0.23*** |
SBP, mm Hg | 120 ± 14 | 123 ± 12 | 122 ± 15 | 121 ± 16 |
DBP, mm Hg | 64 ± 12 | 71 ± 10*** | 72 ± 10*** | 71 ± 12* |
Heart rate, beats/min | 75 ± 14 | 74 ± 13 | 78 ± 15 | 76 ± 15 |
TR, cm/s | 2.6 ± 0.34 | 2.5 ± 0.20 | 2.5 ± 0.27 | 2.4 ± 0.29* |
RVSP, mm Hg | 33 ± 7.2 | 30 ± 4.4 | 31 ± 5.8 | 29 ± 5.5 |
LVEDD, mm | 51 ± 4.9 | 49 ± 4.6* | 48 ± 4.8*** | 48 ± 4.9*** |
LVESD, mm | 33 ± 4.2 | 34 ± 5.3 | 33 ± 6.5 | 33 ± 4.0 |
LVEDV/BSA, mL/m2 | 83 ± 22 | 69 ± 21*** | 68 ± 20*** | 65 ± 18*** |
LV mass index, g/m2 | 101 ± 27 | 90 ± 25 | 86 ± 25*** | 89 ± 22** |
LA volume index, mL/m2 | 46 ± 14 | 36 ± 18* | 38 ± 15*** | 36 ± 12*** |
EF, % | 65 ± 4.9 | 57 ± 5.1*** | 58 ± 6.1*** | 60 ± 5.2*** |
CO, L/min | 6.1 ± 1.9 | 5.1 ± 1.2 | 5.7 ± 1.6 | 5.6 ± 1.9 |
E/A ratio | 1.7 ± 0.6 | 1.5 ± 0.5 | 1.4 ± 0.5* | 1.5 ± 0.5 |
Sep E/e′, cm/s | 10.8 ± 2.6 | 9.3 ± 2.3*** | 8.7 ± 2.0*** | 9.1 ± 2.0*** |
Lat E/e′, cm/s | 16 ± 3.9 | 15 ± 4.6 | 14 ± 4.2 | 14 ± 3.2* |
Hemoglobin, g/dL | 9.5 ± 0.9 | 11.3 ± 2.0*** | 11.7 ± 2.1*** | 12.3 ± 1.9*** |
Total bilirubin, mg/dL | 2.1 ± 3.1 | 0.4 ± 0.3*** | 0.6 ± 0.3*** | 0.5 ± 0.3*** |
Serum creatinine, mg/dL | 1.0 ± 1.5 | 1.4 ± 2.3*** | 1.5 ± 3.1*** | 1.4 ± 2.8*** |
Reticulocyte count, % | 3.5 ± 2.8 | 2.1 ± 1.5*** | 2.2 ± 1.3 | 2.0 ± 1.2 |
LDH, U/L | 338 ± 122 | 248 ± 80*** | 253 ± 127*** | 208 ± 61***,^^ |
6-min walk, m | 509 ± 81 | 501 ± 98 | 525 ± 113 | 544 ± 83** |
P ≤ .05, **P ≤ .01, ***P ≤ .005 for follow-up studies compared with baseline echo.
P ≤ .05 and ^^P ≤ .01 for 3- vs 6-month studies and 6 vs 12 months.