Figure 4.

Cluster-specific DMRs are enriched for distinct regulatory genome segments in reference CD34⁺ cell epigenome. Cluster-specific DMRs display distinct enrichment and patterns of differential methylation at epigenetic regulatory segments in a reference hematopoietic stem cell as defined by the chromHMM 15-state genome segmentation model created from integrated epigenetic datasets (Roadmap Consortium). Clusters with significant positive enrichment of DMRs within a given segment are highlighted in light yellow. Enh, enhancer; Transcr., transcribed; TSS, transcription start site; ZNF, zinc finger protein genes; darker colored bars, hypermethylated DMRs; lighter colored bars, hypomethylated DMRs; gray bars, expected counts, which is defined as (number of cluster-specific DMRs) × ([number of CpG tiles within the given genome segment]/[all CpG tiles covered]).