Table 4.
Multivariate analysis to determinate the independent prognostic factors in entire group with residual rectal cancer patients after preoperative CRT
| Variable | Category | Recurrence free survival (multivariate analysis) |
Cancer-specific survival (multivariate analysis) |
||||
|---|---|---|---|---|---|---|---|
| p-value | HR | 95% CI | p-value | HR | 95% CI | ||
| Pathologic TNM stage | III vs. I&II | 0.105 | 1.744 | 0.890-3.418 | 0.004 | 3.413 | 1.484-7.851 |
| Residual tumor size (cm) | ≥6 vs. <6 | 0.049 | 1.753 | 1.003-3.064 | 0.020 | 2.371 | 1.143-4.919 |
| Venous invasion | Present vs. absent | <0.001 | 20.425 | 5.140-81.172 | 0.086 | 2.767 | 0.865-8.854 |
| Lymphatic invasion | Present vs. absent | 0.889 | 1.050 | 0.528-2.089 | 0.875 | 0.939 | 0.427-2.063 |
| Perineural invasion | Present vs. absent | 0.117 | 1.667 | 0.880-3.157 | 0.009 | 2.634 | 1.271-5.458 |
| CRM | Positive vs. negative | <0.001 | 3.613 | 2.034-6.418 | <0.001 | 4.133 | 2.027-8.426 |
| Tumor regression grade | 0&1 vs. 2&3 | 0.425 | 1.311 | 0.673-2.555 | 0.368 | 1.404 | 0.670-2.941 |
CRT, chemoradiotherapy; HR, hazard ratio; CI, confidence interval; TNM, tumor, node, metastasis. vs., versus; CRM, circumferential resection margin.