Figure 2.

Differentially expressed genes after celecoxib treatment and KEGG pathways analysis. (A) Heat-map of all the differentially expressed genes after celecoxib treatment, there were 50 downregulated genes and 141 upregulated genes. (B) The P-values and names of the top 10 over-represented KEGG pathways, calculated on the basis of all the differentially expressed genes after the treatment of celecoxib. (C) Expression of PNO1 after celecoxib treatment analyzed by western blot. * P<0.05 between celecoxib-treated and non-treated animals. KEGG – Kyoto Encyclopedia of Genes and Genomes; PNO1 – RNA binding gene partner of NOB1.