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. 2019 Sep 30;25:7351–7360. doi: 10.12659/MSM.919218

Figure 4.

Figure 4

Effects of PNO1 knockdown on lung metastasis and AKT/mTOR signaling. (A) Hematoxylin/eosin staining showed that PNO1 knockdown significantly decreased the number of metastatic nodules in the lung (arrow) compared with the negative control and the control mice (image magnification 100×). (B) Levels of P-AKT, mTOR and COX-2 detected by western blot in tumor tissues 6 weeks after PNO1 knockdown. * P<0.05 between negative control or control. PNO1 – RNA binding gene partner of NOB1; AKT – protein kinase B; mTOR – mammalian target of rapamycin; COX-2 – cyclooxygenase-2.