Table 1. Cumulative Risk of Febrile Seizures, Epilepsy, Psychiatric Disorders, and Death in Children Born in Denmark Between 1977 and 2011.
| Exposurea | Total No. | Febrile Seizures | Epilepsy | Psychiatric Disorders | Death | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | 5-y Cumulative Risk, % (95% CI)b | No. (%) | 30-y Cumulative Risk, % (95% CI)b | No. (%) | 30-y Cumulative Risk, % (95% CI)b | No. (%) | 30-y Cumulative Risk, % (95% CI) | |||
| All Children | ||||||||||
| All | 2 103 232 | 75 593 (3.6) | 3.6 (3.6-3.6) | 34 935 (1.7) | 2.2 (2.1-2.2) | 231 435 (11.0) | 17.2 (17.2-17.3) | 14 161 (0.7) | 1.0 (0.9-1.0) | |
| After first febrile seizure | 75 593 | 17 153 (22.7) | 22.7 (22.4-23.0) | 3873 (5.1) | 6.4 (6.2-6.6) | 9542 (12.6) | 21.4 (21.0-21.9) | 476 (0.6) | 1.2 (1.0-1.3) | |
| After second febrile seizure | 17 153 | 6097 (35.5) | 35.6 (34.9-36.3) | 1507 (8.8) | 10.8 (10.2-11.3) | 2384 (13.9) | 25.0 (24.0-26.1) | 123 (0.7) | 1.4 (1.2-1.8) | |
| After third febrile seizure | 6097 | 2647 (43.4) | 43.5 (42.3-44.7) | 777 (12.7) | 15.8 (14.6-16.9) | 960 (15.7) | 29.1 (27.2-31.0) | 52 (0.9) | 1.9 (1.4-2.7) | |
| Girls | ||||||||||
| All | 1 024 049 | 33 343 (3.3) | 3.3 (3.2-3.3) | 16 787 (1.6) | 2.2 (2.1-2.2) | 117 121 (11.4) | 18.8 (18.7-18.9) | 5039 (0.5) | 0.7 (0.6-0.7) | |
| After first febrile seizure | 33 343 | 7308 (21.9) | 22.0 (21.5-22.4) | 1730 (5.2) | 6.5 (6.2-6.9) | 4273 (12.8) | 23.5 (22.8-24.2) | 152 (0.5) | 0.8 (0.7-1.0) | |
| After second febrile seizure | 7308 | 2520 (34.5) | 34.6 (33.5-35.7) | 667 (9.1) | 11.2 (10.3-12.1) | 1006 13.8) | 27.2 (25.5-29.0) | 36 (0.5) | 1.0 (0.6-1.5) | |
| After third febrile seizure | 2520 | 1104 (43.8) | 43.9 (42.0-45.8) | 336 (13.3) | 16.2 (14.5-18.0) | 376 (14.9) | 30.5 (27.4-33.6) | 15 (0.6) | 1.5 (0.8-2.7) | |
| Boys | ||||||||||
| All | 1 079 183 | 42 250 (3.9) | 3.9 (3.9-4.0) | 18 148 (1.7) | 2.2 (2.1-2.2) | 114 314 (10.6) | 15.8 (15.7-15.9) | 9122 (0.8) | 1.3 (1.2-1.3) | |
| After first febrile seizure | 42 250 | 9845 (23.3) | 23.4 (23.0-23.8) | 2143 (5.1) | 6.2 (6.0-6.5) | 5269 (12.5) | 19.9 (19.3-20.4) | 324 (0.8) | 1.4 (1.2-.16) | |
| After second febrile seizure | 9845 | 3577 (36.3) | 36.4 (35.5-37.4) | 840 (8.5) | 10.5 (9.7-11.2) | 1378 (14.0) | 23.4 (22.1-24.7) | 87 (0.9) | 1.8 (1.4-2.3) | |
| After third febrile seizure | 3577 | 1542 (43.1) | 43.2 (41.6-44.8) | 441 (12.3) | 15.4 (14.0-17.0) | 584 (16.3) | 28.1 (25.7-30.5) | 37 (1.0) | 2.3 (1.5-3.3) | |
a
These groups are not mutually exclusive but represent nested groups of children.
b
Cumulative incidences were estimated using competing risks regression, with deaths treated as competing events.