Table 1.

Neurodevelopmental roles for each of the MAR ASD antigenic protein targets

Antigenic protein target	Neurodevelopmental role
LDH	Metabolism, astrocytic glycogen and glucose metabolisms, and their coupling to neuronal functions via lactate for long-term memory formation [77, 78]
STIP1	Neuritogenesis and neuronal survival [79–82]
CRMP1	Cell migration, growth cone collapse [54, 55, 83, 84]
CRMP2	Axon outgrowth, growth cone collapse, basal dendrite patterning [54, 83]
YBX1	Transcription regulation, neural tube formation, cell division [85]
GDA	Dendritic branching [86, 87]

LDH lactate dehydrogenase, STIP1 stress-induced phosphoprotein 1, CRMP collapsin response mediator protein, YBX1 Y-box-binding protein 1, GDA guanine deaminase