Table 2.

ASD-relevant behaviors in the antigen-driven mouse model of MAR ASD

Behavioral assay	Time point	Observed behavioral phenotype of MAR-ASD offspring
Developmental milestones	Pre-weaning (PD 4–14)	Increased biparietal width (head size)
Separation-induced ultrasonic vocalizations	Pre-weaning (PD 4–12)	Increased number of emitted USVs in MAR-ASD females
Juvenile reciprocal social interactions	Adolescence (PD 25)	Decreased social behaviors
		Increased repetitive self-grooming behaviors
Male-female social interactions	Adulthood (PD 45+)	Decreased social behaviors
		Decreased number of emitted USVs by males
		Increased repetitive self-grooming behaviors
Three-chambered social approach task	Adulthood (PD 45+)	No differences
Measures of general health and neurological reflexes	Adulthood (PD 45+)	No differences
Empty cage self-grooming behaviors	Adulthood (PD 45+)	Increased repetitive self-grooming behaviors
Marble bury task	Adulthood (PD 45+)	No differences
Morris water maze	Adulthood (PD 45+)	No differences

Summary of a selection of behavioral results generated in the antigen-driven mouse model of MAR ASD [74].