Fig. 7.

Effects of CoCl₂ on synaptic transmission and ictal-like discharges. A, Fluorescence (top) and extracellular field potentials (bottom) were recorded from En in a control slice. Responses evoked by 400 μA applied in deep layer III of the PC were almost completely abolished by bath application of 2 mmCoCl₂. (KH₂PO₄ was omitted from the ACSF for both control and CoCl₂). Eachtrace represents an average of signals from six neighboring detectors averaged over 10 trials. B,Fluorescence traces from the En show an ictal-like discharge evoked by a stimulus of 47 μA applied in layer Ib.Traces show discharges before (top) and immediately after (bottom) application of 10 mm CoCl₂ and 50 μm bicuculline to the site of discharge onset.