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Lack of co-segregation of heat- and capsaicin-sensitivity at the single-channel level. A–C, Records from three inside-out patches that were stimulated consecutively by heat and capsaicin. Patch A responded only to heat, patch B responded only to capsaicin, and patch C responded to both stimuli. Membrane potential was −60 mV. Dotted lines in recordings indicate shut state. D, Pie chart showing percentage of heat- and capsaicin-sensitive membrane patches in a sample of 161 patches.
