Fig. 5.
Plateau/peak ratio. A, The current responses to the agonist application and its coapplication with the blocker at different concentrations ([B] = 3.5, 14, 35, 105, and 350Kd) predicted by model 1 are superimposed. B, The experimental values of the plateau/peak ratio normalized to the control, (IBS/IB0)/(ICS/IC0), are plotted against the degree of the stationary current inhibition, 1 −IBS/ICS, for different TAA. C, (IBS/IB0)/(ICS/IC0) curves predicted by models 1–5 and 5a. Values of parameters forA and C:P0 = 0.09,τwash = 30 msec, andk2 = 1000 sec−1.