Fig. 7.
Modeling of the recovery kinetics in the continuous presence of the agonist. The values of parameters are the same as listed in the legend to Figure 4. A, Recovery kinetics predicted by models 1–5 and 5a. B, Recovery kinetics predicted by model 1 at different open probabilities,P0. The simulated currents atP0 = 0.04, 0.09, 0.2, and 0.5 are presented. C, Recovery kinetics predicted by model 1 at different time constants of the solution exchange,τwash. The simulated currents atτwash = 1, 10, 30, 50, 100, and 200 msec are presented. D, Recovery kinetics predicted by model 1 at different kinetic constants of the blocker dissociation,k2. The simulated currents atk2 = 0.3, 2, 5, 20, 100, and 1000 sec−1 are presented.