Table 2.
Criteria attributing the blocker effect to one of the kinetic models
| Model | Intersection of the control tail current and the tail current after the agonist and the blocker coapplication (Fig.4A, inset) | Channel desensitization criteria | Channel closure criterion, fast component in the falling phase of the overshoot (Fig. 7A) | Agonist dissociation criteria | Examples of the blockers | ||
|---|---|---|---|---|---|---|---|
| The normalized plateau/peak ratio (IBS/IB0)/(ICS/IC0) > 1 (Fig. 5C) | The recovery current overshoot in the continuous presence of the agonist (Fig. 7A) | Agonist dependence (Fig. 9) | Intersection of the control tail current with the tail current in the continuous presence of the blocker (Fig. 11) | ||||
| 1 | + | + | + | + | Increasing | + | TPentA |
| 2 | + | + | + | − | Increasing | + | − |
| 3 | + | − | − | − | Increasing | + | − |
| 4 | + | + | + | − | Decreasing | − | TBA |
| 5 | − | − | − | − | Constant | − | TPA |
| 5a | − | − | − | − | Constant | − | TEA |