Fig. 1.

Mean locomotor activity (LMA) recorded across a 12-h portion of the light and dark phases (ZT7–ZT18) for Cynomolgus macaques (n = 6) treated with either vehicle or the trace amine-associated receptor 1 (TAAR1) partial agonist, RO5263397. a Mean LMA (counts/15-sec) plotted as histograms following treatment with vehicle and three doses of RO5263397 (0.1, 1, and 10 mg/kg, p.o.). b Summary data for vehicle treatment and the three doses studied. Data are represented as mean ± SEM. Red arrow below the abscissa indicates the time of dosing. A 7-day washout period elapsed between treatments. The higher LMA between ZT11 and ZT12 reflects the chairing of the macaques and movement to and from the dosing room by the experimenter 30 min prior to lights off