Fig. 4.

Effects of the trace amine-associated receptor 1 (TAAR1) partial agonist RO5263397 on performance of the delayed-match-to-sample (DMTS) working memory task in Cynomolgus macaques. Overall a ‘choice’ accuracy (% correct), b ‘choice’ reaction time, and c number of omissions during both 2 and 10 s delay intervals following the administration of vehicle (0.3% Tween 80 in sterile water) or RO5263397 (0.1, 1, 10 mg/kg, p.o.) 30 min prior to testing. No main effect of treatment or treatment × delay interaction were observed on any of the measures. A significant main effect of delay was observed on choice reaction time (*p ≤ 0.05). Data are represented as mean ± SEM (n = 7). A 7-day washout period elapsed between treatments