Fig. 2.

Validation of the ELA model. Maternal separation (MS180) increases the corticosterone response to acute restraint stress (a), increases the feeding latency in a novel environment (b), and reduces the total number of BrdU-positive cells in the hippocampus (c) compared to non-separated (NS) animals. MS180 animals do not show reduced sucrose preference in the SPT (d). Data represents the mean ± SEM, #p < 0.05, ###p < 0.001; n = 4–6/group (CORT response), n = 8/group (NSFT), n = 4/group (BrdU), n = 8/group (SPT)