Table 1.
Comparison of [11C]GR103545 VT in the regions of interest between the healthy control and cocaine-use disorder (CUD) subjects
| Comparison of VT (mL/cm3) across groups (HC and CUD) | |||||
|---|---|---|---|---|---|
| Region of interest | Controls (n = 14) | CUD subjects (n = 17) | |||
| Mean | SD | Mean | SD | p | |
| Striatum | 11.34 | 3.07 | 10.31 | 2.33 | 0.30 |
| Ventral striatum | 16.73 | 7.04 | 15.78 | 4.67 | 0.66 |
| Anterior putamen | 13.74 | 3.88 | 12.52 | 2.61 | 0.31 |
| Posterior putamen | 9.24 | 2.34 | 8.70 | 1.87 | 0.48 |
| Anterior caudate | 11.21 | 3.30 | 9.87 | 2.65 | 0.22 |
| Posterior caudate | 6.43 | 1.48 | 6.04 | 1.98 | 0.55 |
| Anterior cingulate cortex | 17.77 | 4.70 | 17.42 | 6.32 | 0.86 |
| Dorsolateral prefrontal cortex | 14.99 | 3.95 | 13.42 | 3.60 | 0.25 |
| Medial prefrontal cortex | 15.65 | 4.89 | 14.90 | 4.18 | 0.65 |
| Orbitofrontal cortex | 14.41 | 3.77 | 13.00 | 3.69 | 0.30 |
| Temporal cortex | 14.08 | 4.25 | 12.94 | 3.69 | 0.43 |
| Parietal cortex | 14.00 | 3.60 | 12.69 | 3.32 | 0.30 |
| Occipital cortex | 11.79 | 3.26 | 11.01 | 2.69 | 0.47 |
| Cerebellum | 7.66 | 3.54 | 8.00 | 1.79 | 0.73 |
| Amygdala | 18.02 | 8.54 | 15.28 | 7.07 | 0.34 |
| Hippocampus | 8.08 | 1.86 | 8.12 | 1.75 | 0.96 |
| Thalamus | 5.98 | 1.31 | 5.78 | 1.04 | 0.64 |
No significant difference in VT was seen between the two groups in the striatum or other brain regions. The values presented are mean and SD and the p-values were obtained with a two-tailed unpaired t-test