Table 3.
Comparison of [11C]GR103545 VT in the regions of interest in the CUD group before and after binge dosing of cocaine
| Comparison of pre- and post-binge VT (mL/cm3) | ||||||
|---|---|---|---|---|---|---|
| Region of interest | Pre-binge | Post-binge | Percent change | p | ||
| Mean | SD | Mean | SD | % | ||
| Striatum | 9.98 | 1.95 | 8.08 | 1.91 | −17.7 ± 18.3 | 0.01 |
| Ventral striatum | 14.40 | 3.66 | 11.04 | 3.09 | −16.5 ± 26.7 | 0.05 |
| Anterior caudate | 9.61 | 2.33 | 7.90 | 1.97 | −16.3 ± 18.0 | 0.02 |
| Posterior caudate | 5.78 | 2.13 | 4.38 | 1.09 | −19.9 ± 21.0 | 0.03 |
| Anterior putamen | 12.22 | 2.15 | 10.06 | 2.86 | −17.0 ± 19.5 | 0.01 |
| Posterior putamen | 8.48 | 1.71 | 6.72 | 1.73 | −19.1 ± 20.0 | 0.01 |
| Anterior cingulate cortex | 15.25 | 3.53 | 13.01 | 3.01 | −10.8 ± 25.2 | 0.10 |
| Dorsolateral prefrontal cortex | 12.69 | 2.64 | 11.04 | 2.86 | −10.4 ± 23.4 | 0.12 |
| Medial prefrontal cortex | 13.93 | 3.12 | 11.18 | 2.87 | −16.7 ± 23.3 | 0.03 |
| Orbitofrontal cortex | 12.47 | 2.80 | 11.35 | 3.74 | −5. 4 ± 33.6 | 0.20 |
| Temporal cortex | 12.11 | 2.04 | 10.26 | 2.45 | −13.5 ± 22.2 | 0.05 |
| Parietal cortex | 11.97 | 2.30 | 9.93 | 2.44 | −14.7 ± 22.7 | 0.05 |
| Occipital cortex | 10.50 | 1.95 | 8.57 | 2.11 | −16.9 ± 20.0 | 0.02 |
| Cerebellum | 7.80 | 1.58 | 6.36 | 2.08 | −16.9 ± 20.1 | 0.02 |
| Amygdala | 12.38 | 2.28 | 9.98 | 2.40 | −9.1 ± 38.1 | 0.30 |
| Hippocampus | 7.70 | 1.44 | 6.31 | 1.57 | −15.2 ± 18.0 | 0.04 |
| Thalamus | 5.60 | 0.88 | 4.61 | 0.97 | −16.3 ± 20.0 | 0.01 |
VT was significantly reduced across brain regions using a linear model implemented in the mixed model framework, with no main effect of ROI. A post-hoc paired t-test was performed on the ROI and reported below