TABLE 1.
Case reports identified by the Institute of Medicine describing patients having neurological manifestations associated with high-dosage folic acid sorted by approximate year of treatment with folic acid, which was determined by the year of publication
| Year | Number of subjects | ||||
|---|---|---|---|---|---|
| Publication | Treatment | All | Neurological manifestations | Daily dosage (mg) | |
| Hall and Watkins (42) | 1947 | 1947 | 14 | 3 | 10–15 |
| Heinle and Welch (27) | 1947 | 1947 | 1 | 1 | 10–100 |
| Heinle et al. (43) | 1947 | 1947 | 16 | 2 | 10–40 |
| Spies and Stone (28) | 1947 | 1947 | 1 | 1 | 10 |
| Vilter et al. (26) | 1947 | 1947 | 21 | 4 | 50–500 |
| Berk et al. (31) | 1948 | 1948 | 12 | 3 | 10 |
| Bethell and Sturgis (44) | 1948 | 1948 | 15 | 4 | 5–20 |
| Jacobson et al. (45) | 1948 | 1948 | 1 | 1 | 10–65 |
| Ross et al. (30) | 1948 | 1948 | 4 | 1 | 1.25 |
| Ross et al. (30) | 1948 | 1948 | 15 | 8 | 5–45 |
| Spies et al. (46) | 1948 | 1948 | 38 | 28 | 10 |
| Wagley (22) | 1948 | 1948 | 10 | 8 | 5–600 |
| Fowler and Hendricks (47) | 1949 | 1949 | 2 | 2 | 15–20 |
| Israels and Wilkinson (48) | 1949 | 1949 | 20 | 16 | 5–40 |
| Will et al. (41)1 | 1959 | 1949 | 36 | 16 | 5–10 |
| Schwartz et al. (49) | 1950 | 1950 | 48 | 32 | 5 |
| Chodos and Ross (50) | 1951 | 1951 | 4 | 3 | 1.25 |
| Chodos and Ross (50) | 1951 | 1951 | 12 | 8 | 5–30 |
| Conley and Krevans (51) | 1951 | 1951 | 3 | 3 | 4.5–8 |
| Victor and Lear (52) | 1956 | 1956 | 3 | 3 | 1.5–2.55 |
| Best (53) | 1959 | 1959 | 1 | 1 | 10 |
| Crosby (54) | 1960 | 1960 | 1 | 1 | 0.35 |
| Ellison (55) | 1960 | 1960 | 2 | 2 | 0.33–6.4 |
| Baldwin and Dalessio (56) | 1961 | 1961 | 1 | 1 | 0.5 |
| Allen et al. (57) | 1990 | 1990 | 3 | 3 | 0.4–1 |
| Grand total | 284 | 155 | |||
1
Article includes 16 case reports from the 1940s that were assigned to 1949.