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. Author manuscript; available in PMC: 2020 Mar 11.
Published in final edited form as: Nature. 2019 Sep 11;573(7774):434–438. doi: 10.1038/s41586-019-1553-0

Extended Data Figure 2. Results of genome-wide CRISPRi screens for host factors crucial for CDN stimulation.

Extended Data Figure 2.

Volcano plots of the gRNA-targeted genes enriched or depleted in the tdTomato reporter-low versus reporter-high groups after stimulation with 2’3’-RR CDA (a), or 2’3’-cGAMP (b). FC: fold change. Each panel represent the combined results of two independent screens. Calculations of phenotypes and Mann-Whitney p-values were performed as described in the Methods section.