Fig. 5.

Region of interest (ROI)-based analysis of LPS in the first NREM sleep episode following GHB and placebo administration (n = 18). Based on the results of the CSD analysis, a network of six cortical brain regions was significantly modulated by GHB in the theta range (4.5–8 Hz). This network included the anterior and posterior cingulate gyri, the left and right dorsolateral prefrontal cortices, and the left and right parahippocampal gyri, which were defined as ROIs. The red lines indicate significantly increased LPS between ROIs after GHB when compared with placebo. A, anterior; I, inferior; L, left; P, posterior; R, right; S, superior