Fig. 5.

demonstrates that one seemingly true result from the candidate gene era (about DRD2 and schizophrenia) was not actually supported by GWAS results. The orange line denotes genome-wide significance (−log₁₀(5 × 10⁻⁸) = 7.3), and multiple variants on the right side of the figure exceed genome-wide significance. Each point in the figure denotes one genetic variant on chromosome 11 in the region around the D2 dopamine receptor gene (DRD2). The fact that multiple variants exceed genome-wide significance reflects linkage disequilibrium (i.e. correlated alleles). Linkage disequilibrium does not extend, however, to the candidate polymorphism on the left, denoted by the long arrow