Table 3. Relationship between clinicopathologic characteristics of tumor and expression levels of miR-382 and miR-210 in gastric adenocarcinoma with intestinal type of Lauren classification.
| Intestinal type | |||||||
|---|---|---|---|---|---|---|---|
| Clinicopathological | All | microRNA-382 | p | microRNA-210 | p | ||
| Characteristics | n (%) | Low expression | High expression | Low expression | High expression | ||
| n (%) | n (%) | n (%) | n (%) | ||||
| Age at diagnosis, years | 0.197 | 1.000 | |||||
| <63 | 26 (38.8) | 22 (36.1) | 4 (66.7) | 19 (39.6) | 7 (36.8) | ||
| ≥63 | 41 (61.2) | 39 (63.9) | 2 (33.3) | 29 (60.4) | 12 (63.2) | ||
| Sex | 0.639 | 0.538 | |||||
| Male | 50 (74.6) | 46 (75.4) | 4 (66.7) | 37 (77.1) | 13 (68.4) | ||
| Female | 17 (25.4) | 15 (24.6) | 2 (33.3) | 11 (22.9) | 6 (31.6) | ||
| EGCa vs AGCb | 0.013 | 0.002 | |||||
| EGC | 45 (67.2) | 44 (72.1) | 1 (16.7) | 38 (79.2) | 7 (36.8) | ||
| AGC | 22 (32.8) | 17 (27.9) | 5 (83.3) | 10 (20.8) | 12 (63.2) | ||
| Pathologic T category | 0.032 | <0.001 | |||||
| pT1-T2 | 50 (74.6) | 48 (78.7) | 2 (33.3) | 42 (87.5) | 8 (42.1) | ||
| pT3-T4 | 17 (25.4) | 13 (21.3) | 4 (66.7) | 6 (12.5) | 11 (57.9) | ||
| Pathologic N category | 0.011 | 0.038 | |||||
| pN0 | 54 (80.6) | 52 (85.2) | 2 (33.3) | 42 (87.5) | 12 (63.2) | ||
| pN1-3 | 13 (19.4) | 9 (14.8) | 4 (66.7) | 6 (12.5) | 7 (36.8) | ||
| Pathologic stage | 0.004 | <0.001 | |||||
| I | 47 (70.1) | 46 (75.4) | 1 (16.7) | 40 (83.3) | 7 (36.8) | ||
| II | 16 (23.9) | 13 (21.3) | 3 (50.0) | 7 (14.6) | 9 (47.4) | ||
| III | 4 (6.0) | 2 (3.3) | 2 (33.3) | 1 (2.1) | 3 (15.8) | ||
| Lymphovascular invasion | 0.005 | 0.009 | |||||
| Negative | 56 (83.6) | 54 (88.5) | 2 (33.3) | 44 (91.7) | 12 (63.2) | ||
| Positive | 11 (16.4) | 7 (11.5) | 4 (66.7) | 4 (8.3) | 7 (36.8) | ||
| Venous invasion | 0.020 | 0.020 | |||||
| Negative | 64 (95.5) | 60 (98.4) | 4 (66.7) | 48 (100.0) | 16 (84.2) | ||
| Positive | 3 (4.5) | 1 (1.6) | 2 (33.3) | 0 (0) | 3 (15.8) | ||
| Perineural invasion | 0.004 | 0.020 | |||||
| Negative | 62 (92.5) | 59 (96.7) | 3 (50.0) | 47 (97.9) | 15 (78.9) | ||
| Positive | 5 (7.5) | 2 (3.3) | 3 (50.0) | 1 (2.1) | 4 (21.1) | ||
a Early gastric carcinoma;
b Advanced gastric carcinoma.