Table 4. Relationship between clinicopathologic characteristics of tumor and expression levels of miR-382 and miR-210 in gastric adenocarcinoma with diffuse type of Lauren classification.
| Diffuse type | |||||||
|---|---|---|---|---|---|---|---|
| Clinicopathological | All | microRNA-382 | p | microRNA-210 | p | ||
| Characteristics | n (%) | Low expression | High expression | Low expression | High expression | ||
| n (%) | n (%) | n (%) | n (%) | ||||
| Age at diagnosis, years | 0.769 | 0.003 | |||||
| <63 | 59 (58.4) | 52 (59.1) | 7 (53.8) | 49 (68.1) | 10 (34.5) | ||
| ≥63 | 42 (41.6) | 36 (40.9) | 6 (46.2) | 23 (31.9) | 19 (65.5) | ||
| Sex | 0.639 | 0.481 | |||||
| Male | 71 (70.3) | 62 (70.5) | 9 (69.2) | 49 (68.1) | 22 (75.9) | ||
| Female | 30 (29.7) | 26 (29.5) | 4 (30.8) | 23 (31.9) | 7 (24.1) | ||
| EGCa vs AGCb | 0.228 | <0.001 | |||||
| EGC | 42 (41.6) | 39 (44.3) | 3 (23.1) | 38 (52.8) | 4 (13.8) | ||
| AGC | 59 (58.4) | 49 (55.7) | 10 (76.9) | 34 (47.2) | 25 (86.2) | ||
| Pathologic T category | 0.016 | 0.001 | |||||
| pT1-T2 | 56 (55.4) | 53 (60.2) | 3 (23.1) | 48 (66.7) | 8 (27.6) | ||
| pT3-T4 | 45 (44.6) | 35 (39.8) | 10 (76.9) | 24 (33.3) | 21 (72.4) | ||
| Pathologic N category | 0.360 | 0.003 | |||||
| pN0 | 62 (61.4) | 56 (63.6) | 6 (46.2) | 51 (70.8) | 11 (37.9) | ||
| pN1-3 | 39 (38.6) | 32 (36.4) | 7 (53.8) | 21 (29.2) | 18 (62.1) | ||
| Pathologic stage | 0.013 | 0.006 | |||||
| I | 46 (45.5) | 43 (48.9) | 3 (23.1) | 39 (54.2) | 7 (24.1) | ||
| II | 34 (33.7) | 31 (35.2) | 3 (23.1) | 23 (31.9) | 11 (37.9) | ||
| III | 21 (20.8) | 14 (15.9) | 7 (53.8) | 10 (13.9) | 11 (37.9) | ||
| Lymphovascular invasion | 0.113 | 0.108 | |||||
| Negative | 68 (67.3) | 62 (70.5) | 6 (46.2) | 52 (72.2) | 16 (55.2) | ||
| Positive | 33 (32.7) | 26 (29.5) | 7 (53.8) | 20 (27.8) | 13 (44.8) | ||
| Venous invasion | 0.242 | 1.000 | |||||
| Negative | 99 (98.0) | 87 (98.9) | 12 (92.3) | 71 (98.6) | 28 (96.6) | ||
| Positive | 2 (2.0) | 1 (1.1) | 1 (7.7) | 1 (1.4) | 1 (3.4) | ||
| Perineural invasion | 0.041 | 0.561 | |||||
| Negative | 84 (83.2) | 76 (86.4) | 8 (61.5) | 61 (84.7) | 23 (79.3) | ||
| Positive | 17 (16.8) | 12 (13.6) | 5 (38.5) | 11 (15.3) | 6 (20.7) | ||
a Early gastric carcinoma;
b Advanced gastric carcinoma.