Table 1. Top 15 light HNSCC mutation enriched pathways.

Pathway	Number of Mutated Genes	Proportion Pathway Mutated	Proportion of HNSCC cohort with ≥1 mutated gene in pathway	Number of patients with ≥1 mutated gene in pathway
Nephrin interactions	22	1	0.35502959	180
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19	1	0.28796844	146
Constitutive Signaling by EGFRvIII	15	1	0.2800789	142
TRP channels	25	1	0.24457594	124
Ras activation uopn Ca2+ infux through NMDA receptor	17	1	0.23076923	117
Unblocking of NMDA receptor, glutamate binding and activation	17	1	0.21893491	111
Kinesins	27	1	0.21696252	110
Caspase-mediated cleavage of cytoskeletal proteins	12	1	0.20512821	104
Sema3A PAK dependent Axon repulsion	16	1	0.19329389	98
CRMPs in Sema3A signaling	16	1	0.16962525	86
DSCAM interactions	11	1	0.15384615	78
Growth hormone receptor signaling	24	1	0.14201183	72
Mitotic Telophase/Cytokinesis	14	1	0.13806706	70
Na+/Cl- dependent neurotransmitter transporters	19	1	0.12031558	61
Recycling of bile acids and salts	15	1	0.11637081	59

Light pathways ranked first according to proportion of pathway mutated and second according to proportion of cohort with mutated gene.