Fig. 2.

Mice lacking mGlu₂ are resilient to developing stress-induced escape deficits and social defeat stress-induced anhedonia. Mice lacking mGlu₂ (Grm2^−/−) are resilient to developing (a–c) acute corticosterone (CORT, 10 mg/kg)-induced escape deficits (see a for timeline; b, failures over time; c, total failures n = 16/group) and (d, e) chronic social defeat stress (CSDS)-induced sucrose preference deficits (see d for timeline; n = 11–14/group). Grm2^−/− mice do not have (f) altered plasma CORT levels at baseline (Ctrl, unstressed mice) or following inescapable shock stress (n = 5–8/group). Data are mean ± SEM. *p < 0.05, ***p < 0.001. See Table S1 for reporting of statistical analyses and sample sizes per sex