Fig. 3.
Mice lacking mGlu2 do not have alterations in locomotor activity, sensitivity to shock, or passive avoidance behavior. Mice lacking mGlu2 (Grm2−/−) do not manifest deficits in (a, b) open-field locomotor activity (a, distance over time; b, total distance travelled; n = 10–14/sex and genotype), (c) pain sensitivity to shock (n = 12–14/sex and genotype), or (d) escape latency in the passive avoidance test (n = 3–5/sex and genotype), compared with wild-type (WT) mice. Independent of genotype, female mice have higher locomotor activity (a, b), lower threshold for shock response (c), and higher escape latency in the passive avoidance test (d) than males. (Data are mean ± SEM. *p < 0.05, ***p < 0.001. See Table S1 for reporting of statistical analyses and individual sample sizes